With a whopping £20m bounty on the line, Celtic will be throwing everything at the Kazakhstan side as they attempt to find a foothold back into a tie that is on a knife-edge. Many expect that Celtic will score goals tonight; keeping them out at the other end may be a little harder.
McManus was a member of the Celtic side who were shocked 5-0 by Artmedia Bratislava as Gordon Strachan had barely got his feet in the door at Parkhead. Celtic battered them in the return leg but ultimately went out of the competition on a 5-4 aggregate scoreline.
The former Celtic captain believes Celtic are capable of another massive effort again tonight - and he is well aware that it is to the benefit of everyone in Scottish football to have a representative in the elite group stages of the Uefa Champions League.
"I do believe they can do it," he said. "It's not out of their hands yet. I know Neil Lennon and I know that he will expect everyone to burst a gut tonight to get them through. They can do it. It won't be easy, but they can do it.
"There is nowhere like Celtic Park on a European night and it reflects well on Scottish football if we can have teams in there mixing it with the best.
"For me, that night against Artmedia Bratislava was a real turning point on my career. It was a nightmare out there, but it was the start of me getting a run of games together and playing every week. I never really looked back after that."
Back in Scottish football now with Stuart McCall's side, McManus has told the Fir Park supporters that it will still take him a little bit of time to get back to full speed.
The defender has not played regularly since April, but is in the early stages of establishing a decent partnership with Shaun Hutchinson - and he knows now what it feels like to be one of the veterans at a club.
"I am getting there slowly but surely," said McManus. "It was always going to take me time to get back into the swing of things because I haven't been playing regularly for so long.
"But with each game that goes past I feel as though I am getting stronger and fitter and, of course, a wee bit sharper.
"Young Shaun has done really well. These past few years everywhere I go I seem to be one of the older heads in the dressing room - it takes a bit of getting used to!
"The guys around me have done brilliantly. You have to remember that Motherwell lost a lot of players over the summer and brought quite a few of us in so it was never going to be the case where it all came together right away.
"You need a bit of time to allow players to bed in, but we got a good result against a good Partick Thistle side at the weekend and we're looking to continue that with another win this weekend over Kilmarnock.
"The players here set a high benchmark at the club in recent seasons and we want to keep that going."
And McManus has not given up on his international aspirations either.
HE has had dialogue with Scotland boss Strachan - who has had Stevie Hammell in the last few international squads - and he is confident that if he can impress with Motherwell that there could well be an opportunity to add to the 26 caps he has accumulated in his career to date.
"I have always said that I would never close the door on Scotland," he said. "It is an honour to play for your country, but to do that first and foremost you need to be playing every week at club level and playing well.
"I still have a good relationship with Gordon. I have spoken to him and I know what I need to do if I want to get myself back in there.
"It is something that I would never say never about. Right now my priority is with Motherwell.
"It has been a decent start to the season but personally I feel that there is still more to come from me and as a team I think we can do better too.
"We're all looking forward to this weekend's game against Killie and hopefully we can start building a wee bit of momentum now."