Specialist officers from the Marine Policing Unit will be posted on the waterway 24 hours a day during Scotland's biggest security operation.
Fast response boats will be drafted in, although police say there is no specific threat linked to the river.
It is understood officers will rehearse a string of high-speed drills as preparations get under way.
A massive police operation is already under way to keep Glasgow people - and the city's expected one million visitors - safe during the 11-day sporting events.
Assistant Chief Constable Derek Robertson, who is second in command for policing the Games, said: "Police Scotland and partner organisations are committed to delivering a safe and secure Commonwealth Games.
"Detailed planning has taken place to adopt an appropriate security presence around the country's transport infrastructure, including the River Clyde, which will contribute to event and public safety.
"The policing operation will include the ability to respond as required to different circumstances and incidents.
"This will include the deployment of specialist resources."
Mr Robertson and Deputy Chief Constable Steve Allen, the Games' security director, lead a planning team that will deliver the safety and security operation.
Scores of extra officers will be on duty from the arrival of the Queen's Baton on June 14 until the closure of the Athletes Village on August 5.
The Games will be held at 14 venues - including some outside Glasgow - and security will be provided by a mix of police, military and private sector personnel.
Police have given no details of how Glasgow will be policed during the Games, which officially start on July 23 at Celtic Park and end on August 3 at hampden Park.
Meanwhile, Chief Superintendent Andy Bates has promised to stop criminals cashing in on the Games.
He said: "I don't have any fears there will be an increase in criminality at that time - because we won't let it happen."