The Olympic 10,000 metres and 5,000m champion is instead targeting next year's London Marathon, saying that the Commonwealth Games "is not on my list".
While Farah stopped short of completely ruling himself out of the Glasgow event, he is set to focus on the marathon as he decides whether to make the step up to a new challenge before the 2016 Olympics in Rio.
"I don't know. It just depends how I come off that marathon," he told BBC Radio 5 Live.
"My aim is to do the London marathon and that is what I am fully focused on.
"It's a bonus if I do it, but it is not on my list."
Asked what it would take for him to appear in Glasgow, he added: "I've got to come off the marathon healthy and then I'd make a decision.
"You've just got to choose one race."
Farah's absence would be a blow to organisers of the Commonwealth Games, with the 30-year-old a major draw following his heroics at the London Olympics last year.
Farah followed his Olympic successes by winning the 5,000m and 10,000m world titles in Moscow earlier this year.
The Somalia-born runner is now considering whether to take on the world's best in the marathon, revealing his performance in London would play a key role in any decision to run the 26.2-mile event in Rio.
"It all depends on how London goes," he said.
"(The) Olympics is a big one. After London I'll have a chat to my coach."
Farah has played down suggestions he could break the two-hour barrier for a marathon.
Farah said it was "crazy" to believe he could not only challenge the world record of two hours three minutes and 23 seconds but smash it by completing the 26.2 mile route in under two hours.
"It's pretty crazy to say that in my first ever marathon I'm going to shave three minutes off," Farah said on BBC Breakfast.
"If you look at the world record it's slowly been broken before, from 2:04, 2:03. To say I'm going to shave that off is completely crazy.
"I don't think (two hours) is going to be broken in the next 10 years or even beyond that, maybe even 100 years, because if you think about it, it's really difficult.
"The rumours actually started because my sponsors, Nike, are working on a shoe called 'Sub Two-Hour'. They keep working on that, and that's how the rumours started. I never actually said it."