Glasgow 2014 has confirmed that the ticketl ine will reopen at 10am.
Tickets will be released over three days as part of a phased approach.
The ticket line was suspended on Tuesday following a series of problems. Ticketmaster has now undertaken an extensive programme of investigations and tests to ensure customers will not experience the same problems when the site reopens.
More than 50,000 tickets are still available for events taking place across every day of the Games.
All calls to the ticket hotline will not be free and there will be free postage on all new orders.
Glasgow 2014 Chief Executive, David Grevemberg said: "Over the past few days we've been working with our Official Ticketing Agent Ticketmaster with the aim of re-establishing a positive ticketing sales experience for the many thousands of people who want to be part of the Games.
"While we sold more than 60,000 tickets through our ticketing website and hotline last week and saw the most incredible support and enthusiasm from the public, the experience of purchasing tickets was frustrating and unacceptable for some people.
"With additional measures in place aimed at managing demand and the addition of free postage on all orders and a Freephone Ticketing Hotline, we aim to get back to the business of ensuring remaining tickets are sold and that thousands more people can begin to look forward to experiencing the excitement of the Games.
"While we cannot change the past experience of some of our customers, we do want to thank everyone for their huge support of the Games. In less than three months' time great athletes from across the Commonwealth are coming to Glasgow for a festival of sport on a scale of which Scotland has never experienced before.
"Our focus now is on enabling everyone who wants to be part of one of the world's great sporting parties to be able to secure the tickets to do so."
Chris Edmonds, Chairman Ticketmaster UK said: "We are pleased to confirm that we will be relaunching the Glasgow 2014 Commonwealth Games ticketing website next Wednesday 21 May.
"Our team has been working tirelessly to review, analyse and rectify the issues that were experienced on the site.
"Our priority remains to ensure that customers have the best possible experience when securing their tickets for the Games."