Organisers say the tough restrictions are needed to keep the city moving and protect people and businesses around venues.
Maps have been produced which cover the impact of the measures on all areas of the city where athletes will be going for gold.
They highlight which roads will be closed, where right and left turns will be banned and the routes where competitors and others officially involved with the sporting extravaganza will have priority.
There are also details of the huge number of streets which will have waiting or loading restrictions imposed.
The maps cover Hampden. Scotstoun, Kelvingrove lawn bowls centre and the bandstand, Tollcross International Swimming Centre, Ibrox, Glasgow Green, the SECC precinct and the area which includes Celtic Park, the Emirates Arena and Athletes' Village.
There are also maps for Cathkin Braes mountain bike trails and Strathclyde Country Park.
Glasgow 2014 says the plans have been brought in to ensure residents and workers can park near their homes and businesses.
Parking restrictions will be in place on streets up to 20 minutes from venues with residents issued with free permits.
They will also ensure Games related transport, including that provided for athletes and officials, is able to get to venues in time.
CCTV cameras are being installed along core routes which have been designated as only for the athletes and others involved with the competition.
Motorists which ignore road signs and opt to use the Games routes will face a £30 fine.
Games bosses also want to manage the flow of spectators to and from venues, ensuring they arrive and leave as quickly and safely as possible.
Project manager George Vincent said: "It may not be business as usual but it will be business as unusual and all businesses need to plan ahead."here will be an element of disruption but as long as they plan ahead they will have the information they need.
"If you live or work near a venue, we are putting in place measures to keep your community moving and help make sure you can enjoy being at the very heart of Glasgow's biggest ever celebration.
"We are already working closely with businesses across the city to make sure they know what these changes mean for them and we will be returning to venues next month to talk to local people, share the latest information and answer any questions they have as we approach the Games."
Chamber of Commerce chief executive Stuart Patrick has in the past urged Games bosses to provide businesses with details of parking and travel restrictions to allow them to start planning.
He said: "We don't want the city centre to be a no-go zone for shoppers and visitors so we have been very keen to ensure 'open for business but not business as usual' is the message.
We recognise there are a lot of businesses who will face a degree of disruption which is a absolutely inevitable result of the Games.
"But we are encouraged details of the specific traffic and transport measures around the Games venues are now being revealed."
John Fryer, Glasgow 2014 transport manager, said it is important everyone attended the Games is able to get around the city quickly, safely and easily.
He added: "We are encouraging spectators to walk, cycle, use public transport or a park-and-ride site to get to venues.
"We are also committed to making sure people who live, work and operate businesses in this fantastic city are able to go about their days with minimal impact."
Gordon Arthur, communications boss at Glasgow 2014, warned people may have to rethink their travel plans during the event.
He said: "In the six week run up to the Games the public information will step up in terms of informing people of the need to travel a bit earlier or later and be flexible."
Games bosses estimate there will be around one million extra visitors to Glasgow during Games time.