The media giant is working with Bafta award-winning Lime Pictures, the production team behind Hollyoaks and The Only Way Is Essex, to create a four-part movie called Evermoor.
In a sign of the strength of the British television industry, the movie will be the first made in the UK and broadcast on the flagship US Disney channel.
Billed as a mystery adventure, the film follows American teenager Tara Bailey who has been uprooted from her US home and brought to Evermoor - a beautiful but isolated village on the edge of creepy moors in the middle of England.
As her mother and stepfather are busy unpacking, Tara and her siblings try to adjust to their new home.
But soon they are faced with danger and have to unite to save their new home and family's start in England.
Tricia Wilber, chief marketing officer at The Walt Disney Company Europe and Middle East and Africa, said the film was the organisation's "most ambitious production yet".
David Levine, the company's vice president for programming and production, said: "Evermoor is a hugely exciting project for the team, with a gripping story that I'm sure will captivate our global Disney Channel audience."
Claire Poyser, managing director for Lime Pictures, said: "We are delighted to be the first independent production company in the UK to work with Disney on a live action movie to be aired worldwide including the US.
"Evermoor extends Lime's reputation for producing fantastic children's drama that is inspiring for the whole family."
The film is set to be aired in 160 countries across the world from autumn this year.