The group - known for hits such as Pictures Of Matchstick Men and Rockin' All Over The World - are to appear at this year's Montrose Music Festival.
The English band, who recently released their 100th single since forming in 1968, will perform at Montrose East Links on Friday May 23.
Founding member Francis Rossi said: "Playing live, outdoors is what we love to do.
"We're really looking forward to being part of the Montrose Music Festival, which attracts bands from across the UK, and entertaining our Scottish fans. It's set to be a special concert."
Status Quo played the famous Swiss festival at Montreux in 2009.
The Montrose event, known as Mo Fest, which takes place on May 23 and 24, has in the past attracted acts such as Toploader, Eddi Reader, Deacon Blue and The Proclaimers.
Festival chairman David Paton said the event has grown year on year since it was established in 2008 and this year is set to be "bigger and better than ever before" as they welcome Status Quo to Montrose.
He added: "We're delighted to confirm them as our headline act."
This will be the first time the festival has hosted an outdoor event of this scale in its seven-year history.
Early bird tickets, priced £37, will be available to buy at the Links Hotel in Montrose this Friday and Saturday from 10.30am-12.30pm, or online from 10am on Friday from www.ticketline.co.uk.
The rest of the weekend's entertainment is free of charge, with a range of bands of all styles and genres playing at a range of venues in the town.