The outdoor gigs, which kick off today, are expected to attract more than 100,000 fans to Bellahouston Park in the South Side.
French DJ legend David Guetta is to headline tonight's show supported by Swedish dance sensation Steve Angello.
American indie stars The Killers will be the main act at the final show on Tuesday.
Last year, locals complained of noise and antisocial behaviour by concert-goers after Eminem's performance in the park.
People living up to eight miles from the city green space said they could hear the music, while others reported revellers urinating in their gardens.
Organisers DF concerts and Glasgow City Council have vowed to make this year's show the most successful yet, and have held meetings with locals ahead of the event.
The concert site will be split into zones in a bid to minimise problems, and there will be traffic regulations and strict stewarding.