Knox - who plays Rita Tanner in the ITV soap - was charged following an incident in Knutsford, Cheshire, on March 10.
A Cheshire Police spokesman said the 80-year-old will appear at Macclesfield Magistrates' Court on April 24.
The police spokesman said: "Police have charged an 80-year-old woman with drink driving following an incident in Knutsford on March 10, 2014.
"The woman turned up at Knutsford Police Station in relation to a separate matter and was arrested.
"Barbara Knox from Knutsford was charged yesterday and will appear at Macclesfield Magistrates on April 24, 2014."
The charge comes after Knox's daughter, Maxine Ashcroft, 56, was banned from driving for two years.
Ashcroft, of Lechlade, Gloucestershire, pleaded guilty to drink driving at Macclesfield Magistrates' Court on Wednesday.
Know first appeared in Coronation Street in 1964, and has been a regular face the hit soap since 1972.