STRATHCLYDE University has been offered nearly £7 million funding for its Technology and Innovation Centre.
The European Regional Development Fund (ERDF) is to donate £6.7m towards the £89m flagship centre.
It will bring together academics and international industrial partners to develop renewable energy options.
Glasgow construction firm Lend Lease Ltd has been appointed main contractor behind the project.
Professor Jim McDonald, principal of the university, said : "The centre will be the fullest realisation to date of our work as a leading international technological university.
"The funding we have received from ERDF is an endorsement of the quality of our collaborative research."
The 25,000 sq metre centre, which is due to open in 2014, will be the cornerstone of the International Technology and Renewable Energy Zone – Scotland's hub for global green energy developments.
The triangular, nine-storey building will be constructed on a brownfield city centre site next to the university.
A total of 10% of the workers on the project will come from apprenticeship programmes.
Lend Lease executive general manager Gordon Anderson said: "We are particularly excited about working with the University of Strathclyde to bring sustainable benefit to the local community."
The Scottish Funding Council is contributing £15m to the programme, Scottish Enterprise is contributing up to £11m and the university is providing the final £57m.
Cabinet Secretary for Infrastructure and Capital Investment Alex Neil said: "This project can prove a real boost for our economy."