The new flights come into effect from summer 2013, when passengers from Prestwick will be able to take new routes to Poland’s Warsaw Modlin and Rzeszow.
Edinburgh’s new destinations are Bologna, Beziers, Cagliari, Corfu, Katowice and Santander.
There will also be increased frequency to some existing routes from both airports.
Iain Cochrane, Glasgow Prestwick’s CEO, said: “We’re delighted with Ryanair’s latest commitment to grow its business from Glasgow Prestwick which is another sign of its continuing confidence in our airport.
“The decision to increase its Prestwick operations for next summer, along with new routes to Rzeszow and Warsaw is great news both for the airport and the region too.
“It gives travellers an even greater choice of value-for-money destinations next year and a further boost for the local economy, with more visitors to Scotland coming through the airport gateway.”