Dozens of performances will take place as part of the first Duke Street Expo, on Saturday May 31.
Two main concerts, held in The Everlasting Arms Church and Dennistoun New Parish Church, will act as the festival's anchor events and will be accompanied by smaller shows in other, unlikely venues.
Charity shops, a florist, a tattoo parlour and an Indian restaurant are just a few of the unusual locations which will play host to a range of intimate performances.
The festival has been organised by East End Social, a community group which aims to bring music, art and culture to the area.
Event organiser Stewart Henderson, who runs Glasgow record label Chemikal Underground, said the goal of the day-long event was "to infuse as many places as we could with music performances."
Stewart said: "We've tried to pull a bill of bands together that we thought would appeal to everyone."
Glasgow band Admiral Fallow will take to the stage for an afternoon concert at the The Everlasting Arms Church on Whitehill Street on Saturday May 31. They will be joined by Rick Redbeard of the Phantom Band and hip-hop artist Kobi Onyame.
In the evening, Fife folk artist King Creosote will perform alongside Hot Chip alumni Alexis Taylor and Siobhan Wilson.
Free shows are due to take place up and down the Duke Street all day, starting with a children's theatre show in Denniston Library.
The East End Social hosted a series of tea dances in the Barrowland ballroom last month, which saw Elaine C Smith join residents from across the city on the dance floor.
The comedian and actress showed off her foxtrot skills along with hundreds of others throughout the day.
For more information, visit www.eastendsocial.com