The parade of more than 1000 bikes started and finished at the children's hospital delivering eggs and cuddly toys to the young patients.
It is hoped the 35th annual staging of the event will bring in more than £20,000 to Yorkhill Children's Charity.
Thousands of people lined the streets in brilliant sunshine to watch the parade pass.
Bikers dressed as superheroes, Easter chicks and bunnies and even a knight in armour.
They travelled from across Scotland to take part in what has become a highlight of the Easter break.
Kirsten Sinclair, head of fundraising for Yorkhill Children's Charity, said: "We are incredibly grateful to the biking community for their generous support over the past 35 years.
"Every penny donated makes a real and lasting difference and on this special anniversary year we hope to try and raise as much as possible for the incredibly brave and inspirational children who will be spending Easter at Yorkhill."
Fundraiser Aileen McConnell said it took about 40 minutes for the 1000-plus motorbikes to make their way out of the hospital grounds.
She said: "It was a real spectacle and very moving. It is not just the sight but the smell and the sound which can be overwhelming."
Sunny weather experienced over the Easter weekend is expected to fade today when temperatures drop to 13ÚC today with cloud forecast.