It comes little more than a month after the end of major roadworks on the busy stretch at Paisley.
This time the St James Interchange – which carries almost 50,000 vehicles daily – will be resurfaced as part of £215,000 in improvements.
Drivers are being warned to expect disruption with the speed limit in the area temporarily set at 40mph and changes to the way vehicles enter and exit the motorway.
Amey, which is carrying out the work for Transport Scotland, said "to ensure the safety of the road workers and road users," lane restrictions will be in place from Friday night until Monday morning with work expected to end before the rush hour.
Westbound road users travelling beyond junction 29 will use the off-side lane of the eastbound carriageway.
Westbound traffic heading for the airport, junction 29 and the A737 trunk road will go to the nearside lane and exit the M8 at the normal junctions.
Eastbound traffic will use the nearside lane and the hard shoulder as they approach this stretch. Traffic wishing to exit at junction 29 and the airport will use the hard shoulder.
On the slip roads, Junction 29 westbound will be closed during the works with diversions in place. Drivers aiming to join the M8 at junction 29 westbound will be diverted via A726 Barnsford Road onto the A726 Southbar Road then to the M898 southbound on-slip at Erskine to join the M8 at junc- tion 30, Craigton.
Colin Mackenzie, of Amey said: "These works are vital to help ensure the M8 remains in top condition for years.
"While we do not expect the works to cause any major delays, we advise drivers to plan their journeys and leave extra time to reach their destinations."
The works come just a month after £30m was spent repairing the White Cart Viaduct at the Airport, which saw speed restrictions and lane closures between Boxing Day last year until the end of April.