The two men - understood to be armed with a weapon - threatened staff at the One-O-One shop in Alexandra Parade, Dennistoun, yesterday at about 10.30am.
They made off with a three-figure sum of money. There were no reports of injuries.
Police said the men drove off in a black car.
A Police Scotland spokeswoman said: "At about 10.30am two men entered the premises of One-O-One in Alexandra Parade and threatened a member of staff."
Anyone with information is asked to contact police on 101.