Corinne Hutton, from Lochwinnoch, Renfrewshire, lost her hands and legs below the knee to septicaemia in June last year.
The 43-year-old, her closest friends and family set up Finding Your Feet, a fund to raise money to buy prosthetics and make her Scotland's first "bionic mum".
It aims to raise the £250,000 needed to buy her hi-tech prosthetics to help her regain some mobility.
The money raised will also be used to help others in similar situations improve their lives.
She was joined by her five-year-old son Rory, and around 30 of his classmates from Lochwinnoch Primary School, for the walk yesterday afternoon.
Meanwhile, Glasgow Lord Provost Sadie Docherty was on hand to wave the start flag.
In several months, Corinne is to undergo the UK's first double hand transplant operation.
Corinne said: "I want my wee boy, Rory, to be proud of me. He already tells his friends I will be his X-Mum."
Super-fit Corinne became ill just nine months ago, after a seemingly bad cough turned into double acute pneumonia.
Despite pioneering treatment at Leicester's ECMO unit, septicaemia had poisoned her blood and surgeons were forced to amputate her hands and legs below the knee.
At one point, Corinne's family were told she had only a 5% chance of survival.
In the future, the charity, which will be run by Corinne, will help individuals in similar situations, offering support and counselling.
Visit www.finding yourfeet.net for details.