Dozens of services heading east were shut down last night after signals failed between Hyndland and Partick and at Yoker.
Rail problems were experienced across the North Clyde area as far as Bathgate in the east.
Rush hour commuters were hard hit by the problems, which began shortly after noon yesterday and caused a backlog of delayed services.
Routes operating from Dalmuir via Argyle Street to and from Larkhall, Motherwell and Lanark were also affected.
A Network Rail spokesman said: "We apologise for the disruption to services this evening as a result of ongoing problems with signalling equipment. Engineers are on site and continue to work to fix the problem. We hope to resume normal working as quickly as possible."
Hundreds took to Twitter last night to demand answers for the cancellations.
Scotrail's partnership with SPT and FirstGlasgow came into play and rail users were able to use their tickets on
buses and the underground.
But some routes were not able to be served by bus and Scotrail asked passengers to make their own way home.
The rail operator was also offering discounts to anyone unable to use their ticket.
Shortly after 2pm yesterday, Network Rail tweeted that it had almost fixed the problem.
But the signal fault caused a significant backlog on the affected routes.
The tweet read: "We've fixed the Yoker signalling fault but, sorry, considerable residual delays may remain, we'll work with @ScotRail to resolve ASAP."
But at 4pm the company posted another message that problems were still ongoing.
It said: "Sorry we've got further signalling problems affecting services on a number routes.
"Sorry, we're doing all we can to fix it."
Finally, shortly after 8pm last night, Network Rail announced that the issue had been resolved.