Officers said the dawn raid was the result of intelligence work following information from the local community.
A 25-year-old man was arrested for alleged drugs offences and obstruction.
He is due to appear at Glasgow Sheriff Court today.
As revealed by the Evening Times yesterday, Operation Myriad, a six-month campaign, will target organised criminal gangs, armed thugs and anti-social behaviour.
Assistant Chief Constable Bernard Higgins, warned: "Those who engage in criminal activity disrupt the lives of people in the community.
"The bottom line of Operation Myriad is: now, it's your turn."
The Evening Times was given exclusive access and joined more than a dozen officers yesterday for the first phase of Operation Myriad.
CID and uniformed officers, the majority from Strathclyde Police's B Division, which covers the East End of Glasgow, assembled at London Road police office at 6am, before a convoy of police vehicles moved into the suspect's street in Bridgeton.
We watched as both plain-clothed and uniformed officers used battering rams to force their way into the property, in a high-rise block, in Ruby Street.
As officers made their way into the flat, the suspect threw a bag from the window of the property.
It was retrieved by officers, who were covering the outside of the building.
Minutes later, the 25-year-old man was led from his home, handcuffed, by detectives.
A police spokeswoman said: "Officers discovered a quantity of white powder, suspected to be controlled drugs, at the property."
The substance will now be sent for testing.
Police said the operation sent a strong message to those involved in serious and organised crime in the city.
Detective Sergeant Graeme Haugh, who co-ordinated the early morning raid, said: "We want to get the message out there to the community, that we are listening to your concerns and that we are acting on them.
"Our main objective is to keep people safe, and this is exactly how we do that.
"There is not a single person in this particular community that will not know that we were there, carrying out this operation, and disrupting criminal activity.
"We want those taking part in criminal activities to know that we were there.
"And we want them to know that they could be next.
"Also, the plan put in place to recover material thrown from the window worked very well.
"The operation has been a great success.
Operation Myriad will see every division in Strathclyde Police take part in an intense month of action in a bid to reduce crime at every level.
The blitz is a roll out of Operation Neptune, which was launched last year. It ran again in April of this year, in the north and east of Glasgow and East Dunbartonshire.
Neptune combined high-profile policing with intelligence-led operations and is credited for helping cut serious assaults by almost 34%, and robbery by almost 35%.
Mr Higgins added: "We are totally committed to fighting crime and disrupting the activities and lifestyles of those involved.
"We will be targeting the right people at the right time.
"Officers, including those from the force's specialist units, including road policing, the mounted branch and the marine unit, will be out in force keeping people safe.
"The message to individuals and groups engaged in criminality is this: we will catch you, if not at the time, then through retrospective investigation and CCTV footage."