First Minister, Alex Salmond, will today attend the opening of a new 'sales lab' in the city, by direct marketing firm Aquira.
The firm is creating 220 new posts, to help clients find new customers.
The expansion more than doubles the firm's Glasgow workforce to 420 following an initial announcement of 200 jobs in June.
Mr Salmond said the office was a "fantastic facility" and would help unemployed people in the city.
Aquira's clients include Scottish Power and Vodafone.
Mr Salmond said: "Today Aquira has committed to creating a 220 jobs which will bring their total Scottish workforce to 420 and I look forward to continued work with Aquira to grow their presence in Scotland even further.
"The Sales Lab is a fantastic facility, which includes an important training resource allowing Aquira to meet their commitment to give some of Glasgow's young unemployed a practical and promising career."
The news follows yesterday's announcement that global IT firm CGI is to create 250 new jobs in Glasgow.
The firm is to create an Open Source Digital Services Centre for software development next year.
The 250 jobs will be filled within two to three years to support the projected growth in business that will be delivered from the new centre.
Jobs on offer will range from highly skilled technical and managerial staff, to entry level graduate and apprenticeship opportunities.
Tim Gregory, UK President of CGI said: "The two main reasons we selected Glasgow as for our new centre were the talent pool of highly skilled professionals available in the area, and the support we received from the Scottish Government. We are very excited about the future for this area of our business."
Lena Wilson, chief executive of Scottish Enterprise said: "We're delighted to see Aquira realising its potential and generating new jobs for Glasgow, and we look forward to working with the company as the business continues to grow,"