In the latest incident four people were taken to hospital.
A cyclist, his face covered in blood, was treated at Glasgow Royal Infirmary, while three people in two cars were also checked over for injuries.
A witness to the incident in Springburn Road on Tuesday at 8.30am, said: “The cyclist’s front wheel went in to the pothole.”
Marion Kingsley, 46, from Bishopbriggs, said: “A man was on his push bike.
“I heard an almighty bang. He went over the handlebars.
“His face was covered in blood. I called an ambulance.
“I was on the phone to the emergency services when two cars watching the incident crashed into each other.
“A black car was in front, it slowed down and a green car went into the back of it.
“I then asked them to send more ambulances.
“There was some amount of damage to the car. One bonnet was bashed in.”
The pothole which caused the accident is 4.5in deep and 24in long.
Just 10ft further on is a group of four more potholes of a similar size and depth.
Springburn Road is a dual carriageway with a 40 mile per hour limit, used by many lorries, buses and cars.
Mrs Kingsley is concerned the road remained open after the incident without the pothole being repaired.
She said: “The road is always busy. It’s worrying that it’s still open.
“I always say to my son not to go near that pothole.”
A spokesman for Strathclyde Police, said: “Two road traffic accident reports have been submitted -- one involving a cyclist and one involving two cars.
“It would appear from initial inquiries that the two incidents are related.”
A spokesman for Glasgow City Council said: “It would not be appropriate for us to comment on a police incident at this stage.”
A cyclist said he was concerned a similar accident could happen again.
He said: “As a cyclist, potholes are very dangerous. I worry about flying over the handle bars. By the time you see a pothole it’s too late. It’s just too hazardous at times to cycle in Glasgow.
“I’m a driver too and in the past my shock absorber has been damaged by a pothole.”
In March the Evening Times reported how a cyclist suffered a number of accidents after hitting city potholes.
Dave Holladay, 57, hit one pothole that left him in a wheelchair for six months with a broken hip.
He was awarded £10,000 in damages for injuries suffered on Victoria Bridge at Carrick Quay on the Clyde but says he still has occasional trouble with his damaged hip.
Eglinton Street has several potholes -- one at the junction of Cumberland Street is 5in deep and 40in long.
Neighbouring Cumberland Street also has two large potholes -- the first is 2ft wide and 2in deep. The second is 20in long and 4in deep.
Premier Windscreens Scotland is based in Cumberland Street and has many customers who need their windscreens fixed because of pothole damage.
Robert Boniani, 20, windscreen technician, said: “We see loads of damage. On average we do 10 repairs a day because of potholes. We have changed a fair number of tyres because of potholes.”
In Pollokshaws Road there is another 3ft long pothole which has been filled in. However, the void is opening up again.
The South Side is not the only area of Glasgow to be blighted by potholes -- all across the city potholes are causing problems.
Motorist complain of damage to cars including suspension work, broken AVS systems, shock absorbers and exhausts that have fallen off after driving through potholes.
One of the largest ones in the city is in Gibson Street, at the junction of University Avenue.
At 3.5in deep and measuring nearly 6ft long it is large enough for a grown man to lie in.
The Evening Times’ Pothole Watch is calling for the shocking state of Glasgow’s roads to be addressed.
The Evening Times’ Ripped-Off Glasgow campaign has revealed the extent of botched repair jobs on the city’s streets.
And we have called for utility companies to be heavily fined for failure to reinstate road surfaces properly after carrying out work.
A recent survey for Continental Tyres revealed Glasgow’s potholes are the worst in Scotland.
It also showed that 42% of Glasgow drivers have had their cars damaged by potholes.
In April, the city council pledged £12million, an increase of £8m, to repair the city’s potholes and other damage to street surfaces.
There are now six new patching squads in the city after the council handed out two £1m contracts.
Pothole Watch is part of our Ripped-Off Glasgow campaign- which aims to win the city a fair deal as Scotland’s largest city and industrial powerhouse.