Joss Whedon, who also wrote the 2012 blockbuster film Avengers Assemble, will attend the festival's closing gala, the UK premiere of his film Much Ado About Nothing, on Sunday, February 24.
Tickets for the screening sold out in less than an hour.
Also making an appearance on Glasgow's red carpet will be Oscar-winning director Neil Jordan, whose credits include The Crying Game and Interview With A Vampire.
Joining him to promote vampire thriller Byzantium will be former Bond girl Gemma Arterton, who was in Quantum of Solace, and Saoirse Ronan, who played Hanna in Atonement.
Byzantium will screen as part of the Film4 FrightFest, which is on February 22 and 23 during the festival.
Eli Roth, known for horror film Hostel and Inglourious Basterds, will also be in Glasgow as his film Aftershock gets its UK premiere.
The festival opens on Valentine's Day with a screening of the glossy, 1950s-set, French romcom, Populaire.
The film has already been nominated for six Caesar Awards, including the best first film category for director Regis Ronsard, who will attend the event.
Scots actors David Hayman and James Cosmo will also be in Glasgow.
Hayman is promoting the film Sawney: Flesh Of Man, a modern-day take on the legend of Scottish cannibal Sawney Bean.
Cosmo features in a record five films in this year's programme and will be in conversation about his career.
Glasgow Film Festival runs from February 14 to 24.
See www.glasgowfilm.org for full details and listings.