The ladies lunch is being held at the Radisson Blu Hotel on Sunday.
The annual event was originally inspired by Gordon Ramsay OBE, who is honorary patron of the charity.
It is to be hosted by ITV presenter John Amabile, designer and co-presenter of Peter Andre's 60 Minute Makeover.
The celebration includes a champagne reception and two-course lunch, as well as games and prizes.
There will also be live entertainment followed by a disco.
Presenter John Amabile said: "This amazing lunch helps fund the vital work of the Scottish Spina Bifida Association, which supports more than 3500 children, families and young people throughout Scotland."