Pupils at Newhills Secondary School, in Garrowhill, which caters for children with complex additional support needs, were heartbroken when they found the vandalised garden in which tubs and plant pots were overturned and broken, plants uprooted and strewn around the garden and wind chimes smashed.
Headteacher Alison Lochrie, said: "We have been part of a really big project so we have had lots of people working on it.
"We are a school with pupils with complex additional support needs so we use the sensory garden as a quiet, safe place and as stimulation for the pupils.
"Every classroom, bar one, has a door leading on to the garden so they can go out and use it. In the past it has become overgrown but we have worked really hard this year."
The school, which has 45 pupils, has been working on the garden for the past five months as part of Glasgow City Council's Determined to Grow project.
Apprentices on work experience projects came in to help the older pupils, growing plants from seed inside and then planting them out, while workers from Glasgow Community Safety Services dug and cut back the garden, painted fences and railings and made bird tables, benches and planters.
The garden was specially designed for pupils with complex needs and included herbs with different textures and scents and wind chimes.
Alison said: "I think everyone is very sad, disappointed and upset that our lovely garden that everyone has worked so hard on has been wrecked.
"We know it is only a few people because all the people around here are very supportive of the school.
"It is just a mindless few who have wrecked it.
"The pupils have complex support needs and it is very difficult for them to understand why anyone would want to do this."
Pupils had been planning a celebration of their beautiful new garden next week, but this may have to be put on hold until it can be repaired.
Alison added: "We will clean up and we will just start again.
"It is such a pity that a few people have spoilt it for a lot of children."
Inspector John Gormlie of the Easterhouse Police Office said: "This is a disgusting act of vandalism.
"Police have visited the school and are working closely with the headteacher to offer advice on keeping the garden secure.
"We will be on hand over the coming days to help and will be doing all we can to catch those responsible."
Councillor Stephen Curran, Executive Member for Education and Young People, said: "It is a sad state of affairs when there is a minority of people dead set on causing misery and upset.
"The youngsters at the school have been working really hard to make their garden a nice, peaceful area they can access.
"These are youngsters with complex additional support needs and it really is astonishing that we have yobs out there who would do this kind of thing."
Anyone with any information should contact Easterhouse Police Office on 0141 532 4300.