The annual run - Scotland's largest mass participation running event - will take place in the city on October 5 and is scheduled to be screened live on BBC2 for a second year.
It incorporates both a 10k and half marathon route along some of Glasgow's best known streets, winding past famous landmarks.
Starting at George Square, the event will see some of the world's best known athletes and tens of thousands of club, charity and fun runners take on a route which covers six Commonwealth Games venues before passing under the McLennan Arch to enter Glasgow Green and reach the tree lined finish in the shadow of Nelson's Monument.
Last year a record breaking 30,000 took part in events participants across the weekend.
Given the Great Scottish Run will be the first mass-participation running event after the Commonwealth Games, organisers are confident of another bumper turn-out.
Curling skip David Murdoch and his all Scottish crew - Scott Andrews, Greg Drummond, Michael Goodfellow and Tom Brewster - were at Glasgow Green, the site of the iconic finishing stretch, with last year's first female finisher, Susan Partridge.
In 2013 Susan covered the half marathon route in 1 hour, 10 minutes and 40 seconds and she joined the curlers on their very first training run as they swept the way for her to come back and defend her title.
Susan said: "Last year was particularly special for me and I was thrilled to be the first female finisher alongside the legendary Haile Gebrselassie who clinched the men's title.
"I'm excited to come back this year to defend my position and can't wait to see all the runners out in force along Glasgow's streets."
Three-time Winter Olympian David Murdoch and his silver medal winning Sochi team are aiming to tackle the iconic half marathon route on Sunday, October 5.
The day before the event, Saturday, October 4 also sees the popular Super Saturday returning to the city with a toddler dash, family mile, mini run and junior event.
David Murdoch, a two-time world champion and three-time European champion curler, said he and his team where "slightly apprehensive" about making the move into long distance running.
Executive Member for Commonwealth Games, Councillor Archie Graham, said: "Glasgow has an increasingly strong presence on the world sporting stage and this event has played a key role in building that reputation.
"This is Scotland's flagship festival of running."
Meanwhile, designer Patrick Grant who presents The Great British Sewing Bee on BBC TWO, is getting behind this weekend's Sport Relief effort to encourage people in Glasgow to support those in hardship at home and abroad.
Patrick has completed marathons and last year did the Scotland Coast to Coast iron man triathlon. He has also signed up to do a 400-mile London to Edinburgh challenge. The Sainsbury's Sport Relief Games in Glasgow take place this weekend.