Youngsters from six city schools will take part in the Holocaust Educational Trust's Lessons from Auschwitz Project alongside 180 others from the west of Scotland.
The aim is to give the pupils a greater under-standing of what happened during the Holocaust to learn where prejudice, racism and anti-semitism can lead.
The four-part course, established by HET 14 years ago, began with a seminar focusing on pre-war Jewish life in Europe.
Pupils from Bannerman High, Bellahouston Academy, Hillhead High, Hyndland Secondary, St Roch's Secondary and Hyndland Secondary all took part in the event at Glasgow's Crowne Plaza Hotel.
Hillhead High S6 pupil Delilah Niel said she was looking forward to what would be an "inspirational trip".
The 17-year-old said: "I did Higher history and was really interested in German history so I was keen to take part in the project.
"I think it is really important to see how this affected real peoples' lives.
"I think the trip to Auschwitz is going to be inspirational and change how we look at things, particularly the history of our own country."
Participants also heard the first-hand testimony of Leslie Kleinman, a survivor of Auschwitz-Birkenau.
Based on the premise that "hearing is not like seeing", students will travel to Poland on October 30 to visit Oswiecim, the town where the Auschwitz concentration and death camp is located.
At the camps, participants will visit former barracks and the crematoria, and see the piles of belongings that were seized by the Nazis.
Finally, students will spend time at the main killing centre where the day will conclude with candle lighting and a period of reflection to remember all who died during this chapter of European history.
After their return and a follow-up seminar the students will become Ambassadors for the HET and share their experience with their schools and the wider community.
HET chief executive Karen Pollock MBE, said: "The Lessons from Auschwitz Project is a vital part of our work, allowing young people to learn about the Holocaust in a way they cannot in the classroom.
"The visit enables young people to see for themselves where racism, prejudice and anti-semitism can lead and its importance is demons-trated by the inspiring work students go on to do in their local communities."
Founded in 1988 by Lord Janner of Braunstone and the late Lord Merlyn-Rees, HET was formed during the passage of the War Crimes Act.
One of its achievements was to ensure that the Holocaust was included in the National Curriculum for England.