North Lanarkshire Council has decided to close Abronhill High, and move staff and pupils to the town's Cumbernauld High.
The plans include building a new school on the Cumbernauld High site within four years.
The campaigners are asking the Scottish Government to call in the decision and want ministers to overturn the council plan and keep the school open.
Representatives are due to meet with Cumbernauld and Kilsyth SNP MSP, Jamie Hepburn, before they hand in their petition to education bosses at the Scottish Government.
The council says the closure is necessary as both Abronhill and Cumbernauld schools are under occupied, with almost 1000 empty places and they need to close one to make savings to allow two new campuses in the town to be built, one at Cumbernauld High another at Greenfaulds.
The decision made earlier this month by the council was met with anger from campaigners who do not want the Abronhill area to lose its secondary school.
Mr Hepburn has backed the campaigners previously branding the decision a "disgrace."
The school was made famous in the 1981 hit film Gregory's Girl starring John Gordon Sinclair, Dee Hepburn and Claire Grogan.