The gaping seven foot deep hole at the bottom of Westercraigs was cordoned off and the street sealed.
Scottish Water workers were quickly on the scene and con-tractors were working to effect a repair.
But the damage has caused disruption and inconvenience to local businesses and residents.
Estate agent Lesley Ross, 43, works in a building close to the scene.
She saw some of the problems it caused in nearby Annfield Place and she had trouble getting to work.
She said: "It's a one way street and when I turned on to it, the traffic was queued right back.
"There was also a lot of congestion because people were trying to get to the post office right next to me."
The congestion affected local residents leaving their homes for work and caused problems throughout the day.
Glazer Roddy Montgomery, 56, from Pollok, travelled down the road, hoping to exit on to Duke Street.
He said: "Because the road's shut off I'll need to go back up the hill and come all the way back round.
"Now I'm late for the job I was going to."
A spokesman for Scottish Water said: "We have attended the scene and contractors will be starting work as soon as possible to repair the sewer and the damaged section of road.
"The affected stretch of the road has been closed and fenced off and local diversions are in operation.
"This will remain the case until the repair work is completed.
"We apologise for any inconvenience to road-users in the area and thank them for their patience while we work to resolve the issue."
A spokesman for Glasgow City Council said it was carrying out an investigation into the incident.