Maxwellton Primary School and Greenburn School in East Kilbride have joined together to be Scotland's first purpose-built integrated campus. The £8.7million campus sees the building take up two levels with therapy rooms, a sensory room, a soft play room and a hydrotherapy pool.
Jan McLaren, Maxwellton Primary head teacher, said she and her staff are "utterly delighted" with their new school.
She added: "Pupils are excited at the prospect of the move to a bright, stimulating and motivating working environment. They cannot wait to get in and get started.
"I keep telling everyone that a school is not a building, it is much more than that. But a great school in a beautiful new building and learning environment is about as good as it gets."
The school was built by Kier Construction's Scottish business and was handed over five weeks early. But pupils will not move in until Monday, October 21.
Helen Nicol, head of Greenburn School, added: "The staff and children are very excited about moving in. It is a fantastic opportunity for all, working together in this wonderful new environment."
Construction on the site took place while pupils continued to attend the adjacent Maxwellton and Greenburn schools.
Demolition of the old facilities will take place once pupils have moved. Extra lifts have been installed to allow pupils with additional needs access to the upper floor.
Neutral colours have been used to create a peaceful atmosphere for pupils with additional needs, and there are both hard and soft outdoor play areas.
Councillor Jean McKeown, chairwoman of the Education Resources Committee, said: "I am delighted to see children and staff from both schools moving into their brand new buildings.
A spokesman for South Lanarkshire Council added: "This is another major achievement for the council's schools modernisation programme - arguably the largest in the UK with its £812m investment in creating new and vibrant learning facilities to meet the needs of children."