Darius will perform at the Kiss of Life charity lunch in Glasgow on Friday, January 31, an event which will be hosted by BBC presenter Catriona.
St Andrew's First Aid is holding the lunch at the Grand Central Hotel in association with Cardiac Science.
The Kiss of Life lunch includes a drinks reception, gourmet lunch and entertainment from the West End actor and platinum-selling singer-songwriter.
Darius, best known for his No.1 single Colourblind, was born in Glasgow and rose to fame on the TV talent show Pop Idol, where he was a finalist.
He has since performed in numerous West End productions such as the Olivier Award-winning Guys and Dolls and Chicago.
St Andrew's First Aid's head of fundraising, Helen Forrest, said: "I would like to thank both Darius and Catriona for making the time to support St Andrew's First Aid.
"With the help of such great Scottish celebrities, we hope to raise awareness of the fact that knowledge of CPR skills can make the different between a life lost and life saved.
"The Kiss of Life lunch is a great way to celebrate the start of 2014 and national heart month and with many Scots still in the spirit of making changes in the New Year, if you haven't made your resolution yet, commit to learning First Aid so that together we can save lives."
Cardiopulmonary resuscitation (CPR) is an emergency first aid technique which combines rescue breaths and chest compressions in order to maintain blood and oxygen flow in a person who has suffered cardiac arrest.
CPR and defibrillation greatly improve chances of survival in such cases and both skills can be learned through St Andrew's First Aid.
Guests will be able to take part in a raffle and auction, when prizes such as a signed print by Jack Vettriano and Swarovski jewellery can be won.
Tickets for the lunch cost £45 per person and can be booked by calling 0141 332 4031.