Sections of both the M80 and M77, which are used by nearly 70,000 drivers every week day, will be closed to enable the work to be carried out.
The M80 Glasgow to Stirling route will be closed overnight for four nights at Junction 5 Auchenkilns Interchange.
Resurfacing work will be carried out on both carriageways as well as the northbound and southbound off-slip and on-slip roads. Repairs begin today at 8pm and will be completed by 6am on Tuesday.
Carnie Morrison, general manager of Highway Management (Scotland), said: "These essential maintenance works are being carried out overnight, when traffic flows are reduced, to minimize delays to motorists. We would however encourage motorists to plan their journeys in advance where possible."
Almost 40,000 thousand drivers use this section of motorway each week day, while another 28,000 drivers each day use a section of the M77 which is also being resurfaced this week.
Repairs are planned between Junctions 2, at Silverburn, and 3, Darnley, from tonight until Monday morning. The southbound carriageway will be closed from 8pm until 6am tomorrow to allow workmen to install traffic management procedures.
Motorists will then be allowed to drive past the site, with two lanes open in each direction.
The same stretch will shut again between 10pm on Saturday until 6am on Monday.
Russell Rennie, of contractor Scotland TranServ, said: "We will make every effort to minimise disruption.
"However road users can expect delays if they are travelling to and from Silverburn Shopping Centre towards Junction 3 at Darnley."
Details are available at www.trafficscotland.co.uk or by following @Traffic Scotland on Twitter.