The accident happened at about 4pm yesterday on the A73 Lanark Road, just south of the centre of Carluke.
It is believed that the motorbike hit the stationary vehicle close to a bus stop. There were no passengers on board.
The driver of the bus was not seriously injured.
The A73 Lanark Road was closed both ways for some time after the accident while investigations were carried out. Police directed traffic at the scene.
A spokeswoman for Police Scotland confirmed a male motorcyclist had been killed.