De Vere Village Hotels plans to build a mixed-use development at Pacific Quay and has applied for permission in principal to build housing on the site.
It is understood the hotel, which is near the new BBC HQ, will include a gym, with a 20m indoor pool, a restaurant, bar, coffee shop and conference facilities.
The hotel will have a 270 space car park and a pedestrian and cycle access to the SECC, across the river.
De Vere, which already runs luxury Cameron House Hotel on the banks of Loch Lomond near Balloch, says the new village resort would create 120 jobs.
Robert Cook, chief executive of Village Urban Resorts, said: "We intend to be on site by late March 2014. It is a difficult site involving multiple parties, which are slowly but surely being resolved "
The new hotel is part of a £6bn building bonanza in the city over the past two years.
In that time, four new hotels have been opened and one refurbished, and another five are in the pipeline, at a cost of around £103m.
The biggest investment is in infrastructure, with£1376m is committed to projects which are completed, underway or planned.
They include the £600m spent on improvements to the M74 and M80 and the £253m being spent by Scottish Water on waste water, flood prevention schemes and upgrading mains in the city centre.
Strathclyde Partnership for Transport comes third in the spending league with its £246m upgrade of the Subway, which is under way.
The second biggest area for investments is the £1150m for education, including a £350m development at Strathclyde University, £228m at City of Glasgow college and £250m being spent on council -run primary schools.
Almost £1billion will be spent on residential and student accommodation, including a £250m project in Sighthill, £245m for the Athletes' Village for the Commonwealth Games and £100m of investment by Glasgow Housing Association.
The £928m spend on health projects is mainly due to the new South Glasgow Hospital, which is being built at a cost of £888m.
Spending on office projects totals £597m and leisure £462m, which includes £318m on new and upgraded sports complexes which will be used during the Games, and the new £125m Hydro Arena at the SECC.
Shops account for £408m of the total, with by far the largest development being the planned £310m extension to Buchanan Galleries.
In some areas of investment, Glasgow is outperforming every other city in the UK.
Stuart Patrick, chief executive of Glasgow Chamber of Commerce, said: "UK national figures suggest investment is slow, that government at all levels has slashed its capital budgets and that large corporations are holding onto their cash.
"But one look at this remarkable level of investment in Glasgow shows we are bucking the trend and are a genuine success story."
Scott Taylor, chief executive of Glasgow City Marketing Bureau, welcomed the new hotel.
He said: "Investors know that Glasgow is a safe bet.
"New developments, such as the De Vere Village Urban Resort will, in turn, increase the city's attractiveness to tourists and conference delegates.
"Glasgow is a city that returns a hotel investment at an impressive level, based on the mix of business to the city, and there is plenty more conference, events and short break business in the pipeline to ensure the future profitability of the supply chain."