Ayesha Siddiqui desperately needs a bone marrow transplant, but despite more than 3000 samples from potential donors, none has been a match. As the nine-year-old is half Caucasian and half Middle Eastern, her chances of finding a match are considerably reduced.
Despite their ordeal, the family, from Newton Mearns, East Renfrewshire, has raised almost £172,000 to help the Anthony Nolan Trust process donor samples to help others affected by leukaemia. Mum Noreen, 49, has been shortlisted for Tesco Mum of the Year award for her efforts.
Ayesha is now on her 30th cycle of gruelling chemotherapy and has lost her hair three times.
Blood cancer charity, the Anthony Nolan Trust is holding a donor drive tomorrow at Glasgow Caledonian University to try to find a match for Ayesha.
Dad Nadeem, 51, a cancer specialist at Glasgow Royal Infirmary, said: "Ayesha is now on her 30th cycle of chemotherapy and as you can imagine it's taking its toll, emotionally and physically. It's quite difficult for myself and Noreen but Ayesha's spirit, tenacity and vitality keeps us going.
"She has good weeks and bad weeks. There is one week in every month she on high does steroids and intravenous chemotherapy as well as oral chemotherapy. It's a very difficult week for her.
"The steroids make her diabetic which give her food cravings and make her agitated. She's up at night sometimes. We just have to keep going, we've no choice.
"There will come a point when we will have to stop the chemotherapy and see how she responds. We just want Ayesha to get better."
The family have helped recruit 500 new donors from Glasgow for the bone marrow register since they launched the Ayesha Appeal.
The donor drive is being held from 10am to 4pm on the Mezzanine Floor in the Saltire Building at Glasgow Caledonian University.
The charity is looking for healthy people, 16-30 years, particularly those an ethnic minority/mixed race background.
Ann O'Leary, Head of Register Development at Anthony Nolan, said: "Ayesha's story is one of inspiration and determination. "