Ms Donaldson, creator of The Gruffalo, is returning south to spend more time with her family.
She has lived in Bearsden since 1989.
The former Children's Laureate and her husband Malcolm, a senior researcher in child health at Glasgow University, have already bought a new home in preparation for the move.
They plan to sell the villa where they have lived since moving to Scotland from Bristol, and where Donaldson wrote all her best-known books.
The couple has two sons and four grandchildren - with one family in the Cotswolds and the other in Broughty Ferry, by Dundee - and plan to divide their time between the two.