The £11 million Premier Inn will open ahead of schedule in June at Pacific Quay, Glasgow.
The jobs, including four apprenticeships, range from receptionists and restaurant workers to housekeeping and maintenance staff.
Premier Inn Glasgow cluster general manager Barry Halfpenny said: "Opening in time for the Games has been our aim since plans were first approved for the site, which everyone involved in the project has worked tirelessly to make happen.
"The hotel is in a fantastic location with incredible views both of the city and along the river, which we are confident not only business and leisure travellers will be impressed with but locals too."
The 180-bedroom hotel is located on a three-acre site next to the BBC and STV and opposite the Hydro Arena and SECC.
Premier Inn said that, once open, the Pacific Quay hotel will take the number of Premier Inn bedrooms to more than 1000 in the city centre.
They are based in George Square, Charing Cross, Buchanan Galleries. Argyle Street and City Centre South.
Pacific Quay is one of the chain's three new hotels in Scotland this year.
A new hostelry, due to open in the summer in Stirling and Perth, is part of Premier Inn's expansion project that will see the company extend its number of bedrooms UK-wide from 49,000 to 65,000 by 2016.