Commonwealth Games athlete Lee McConnell and Tourism Minister Fergus Ewing met up with Games mascot Clyde to launch the new venture.
It replaces the existing tourist information centre, which has been located in George Square for 16 years.
The centre has moved to Buchanan Street in advance of 6000 athletes and thousands more visitors arriving in the city for the Commonwealth Games in 2014.
VisitScotland hopes the tips and information on offer at the centre will encourage both locals and visitors to explore more of Glasgow and Scotland as a whole.
Buchanan Street, which has an annual footfall of 91 million people, is the second busiest shopping street in the UK after London's Oxford Street.
The new centre includes a "tablet table" where visitors can browse computer apps, websites and post social media updates on sites such as Facebook or Twitter.
They can access free wi-fi, enjoy a video wall of inspiring local and Scottish attractions, see digital posters promoting local businesses and a 'What's On' feed from VisitScotland about major events in Glasgow and elsewhere in Scotland.
Liz Buchanan, regional director of VisitScotland, said: "Glaswegians are renowned as among the friendliest people in the world and have always been great ambassadors for the country.
"Our new flagship information centre in Buchanan Street is just as much for them as our visitors.
"We want to inspire everyone to holiday here for the Games, make the city come alive and deliver an unforgettable experience so we reap the benefits of the Games in the years beyond 2014."
Mr Ewing said: "The Commonwealth Games is the largest cultural and sporting event we have ever held in Scotland and I want everyone who comes here to have a memorable experience.
"The new VisitScotland centre will make sure the best information is available for those who want to explore Glasgow and further afield."
VisitScotland information centres across the country get around five million visitors each year.
On average, each visitor goes on to spend an extra £5.35, generating more than £24m for Scotland's economy.
vivienne.nicoll@ eveningtimes.co.uk
Comments & Moderation
Readers’ comments: You are personally liable for the content of any comments you upload to this website, so please act responsibly. We do not pre-moderate or monitor readers’ comments appearing on our websites, but we do post-moderate in response to complaints we receive or otherwise when a potential problem comes to our attention. You can make a complaint by using the ‘report this post’ link . We may then apply our discretion under the user terms to amend or delete comments.
Post moderation is undertaken full-time 9am-6pm on weekdays, and on a part-time basis outwith those hours.
Read the rules hereComments are closed on this article