The Scottish Crime and Drug Enforcement Agency said 195 people were arrested in the past year, including 73 of "the most harmful and dangerous criminals".
It also said officers seized 1376.5 kilograms (almost 220stones) of illegal drugs with a street value of £33m – £6m up on the previous year.
A record £1.26m of cash was taken from the pockets of criminals, six times the amounts seized the previous year.
Police also identified criminal assets valued at £9.1m, while a number of offenders were sentenced to a combined 275 years' imprisonment as a result of the agency's investigations.
Among the ringleaders put behind bars over the last year as a result of separate investigations were the cocaine traffickers Sohaib Qureshi, 34, from Bearsden, near Glasgow, who got 12 years, and William Byrne, 25, of Wemyss Bay, Renfrewshire, who received 4½years.
Deputy Chief Constable Gordon Meldrum, the agency's director general, said: "Serious organised crime groups operate as businesses. We are increasing our focus on disruption – doing whatever makes it really difficult for serious organised crime to operate and literally putting them out of business.
"Arresting criminals and taking drugs off the street is still important.
"But organised crime groups do not just deal in drugs – they deal in commodities. That is why our approach has shifted towards building knowledge on a group's activities and networks, and taking disruptive action that then hurts them the most.
"Disruption has included working with our partners to take action on tax evasion, on the leasing of high value cars, on suspending licences for taxis, security firms and haulage, on environmental health, on benefit fraud, on business loans and mortgages, on product safety, and even on animal cruelty.
"The more we collectively disrupt these crime groups' activities, the less violence, robbery, and drug dealing we will see within communities across Scotland."
Scots Justice Secretary Kenny MacAskill said: "Every arrest made related to serious organised crime is a step to getting these groups out of our communities."