PC Alan Long, who is based at London Road police station, will climb 18,000ft - three times the height of Ben Nevis - to the Everest Base Camp for Yorkhill Children's Charity.
And he is hopeful his time walking the beat will keep him fit for the 15-day trek.
Dad-of-one Alan, 35, from Springburn, has been with the police for nearly 10 years.
He said: "In the police you walk miles. On the best of days, if you are out and about on the beat you can easily do seven or eight miles without thinking about it, so walking I can do.
"It is just building up the stamina to do it in more extreme conditions and more difficult terrain."
Alan hopes to raise £4000 for the charity, walking between six and eight hours a day to reach the camp.
He met with Lucy Clift, 14, and 12-year-old Shaun Foy, who are both patients at Yorkhill Children's Hospital, to launch his fundraising campaign ahead of the trek next September.
Alan said: "It is a once in a lifetime opportunity and it is a fantastic charity to do it for. When else would you get the chance to go see that part of the world?
"It should be an incredible experience and a very worthwhile charity is going to gain out of it.
"There can't be many families in Scotland who, directly or indirectly, haven't been affected by the work they do at Yorkhill Hospital."
Joining Alan on the trip is Mhairi Jack, who volunteers alongside Alan with the Army Cadet Force.
Mhairi, 31, from Strathaven, South Lanarkshire, is aiming to complete the trek in memory of her cousin Allan Dunn, who died of cancer in 1994, when he was just 12.
Next year will be the 20th anniversary of Allan's death and she aims to remember him when she reaches the top of the world.
Allan, who was the same age as Mhairi, was treated in Yorkhill Hospital from the age of eight until he passed away.
She said: "I will be thinking of him during the hard times up there. I hope that spurs me on to keep going."
Before they even reach the start of the trek, the friends must face the world's most extreme airport, flying from Kathmandu to Lukla in Nepal.
Once they hit the ground they will face daytime temperatures of around 30 degrees, dropping to minus 10 at night.
THEY will also have to contend with the risk of altitude sickness as they climb higher towards the camp.
The pair have already kicked off their fundraising with a cake sale at Alan's police station and Alan is also doing a sponsored six-month weightloss with the aim of losing a couple of stone.
He said: "We have a whole bundle of different ideas, so it is just a matter of plugging away and hopefully we will reach and pass the £8000 total we hope to achieve."
Kirsten Sinclair, fundraising manager at Yorkhill Children's Charity, thanked Alan and Mhairi for taking part in the challenge.
She said: "The money raised in this fantastic challenge will go towards helping sick children all across the country and beyond."
To donate visit www. yorkhillyetiyomp.co.uk
There are still places available on the Everest Base Camp Trek for Yorkhill Children's Charity.
Participants must raise £3600 for the charity to secure a place.