The Jenny Don't Be Hasty performer joined three children from his home town who receive music therapy from Nordoff Robbins Scotland to mark the launch of the charity's partnership with the SSE Hydro.
He lifted Jamie Nicolson, 7, from Paisley's Kersland Primary, on to his shoulders outside the £125million venue, where he also met Ross Kinney, 12, and Jackson Shepherd, 11.
Nutini said he was a "massive believer" in the power of music. He said: "I've been involved with Nordoff Robbins in Scotland for a few years now and was honoured to be asked to help launch the Make Music Change Lives Campaign at the Hydro."
Nordoff Robbins Scotland helps more than 400 children and adults every week and is the first charitable partnership to be announced by the venue.
John Langford, director of concerts, events and ticketing at the SECC, where the SSE Hydro so located, said: "This is a charity we wholly support and applaud."