Patrick Bradley, 29, was found seriously injured at a house in Greenock, and later died in hospital.
Police believe three or four people were involved in a disturbance at the property on Wellington Street at around 1.15am on Friday.
A second man, aged 37, was injured and taken to Inverclyde Royal Hospital where his condition was described as stable.
Police Scotland are asking for anyone with information to come forward and contact them.
Detective Inspector Una Maider said: "Wellington Street is residential and there is no doubt that people would have either seen or heard the disturbance take place."