Officers swooped on homes in the Govan, Ibrox and Pollok areas and seized drugs with a street value of more than £150,000.
In one flat on Copland Road more than 300 plants were found and a 45-year-old man was detained in connection with the find.
A spokeswoman for Strathclyde Police, said: "Drugs worth an estimated street value of £150,000 have been seized by police in the Govan area of Glasgow.
"Around 7.30am yesterday local officers, acting under warrant, searched a property in Copland Road and recovered a cannabis cultivation.
"A report will be submitted to the procurator fiscal."
Around 30 officers – a mix of plain-clothed, uniform and CID teams – were involved in yesterday's raids.
It was part of Operation Myriad, a six-month crackdown on crime, which is running across communities in the south of Glasgow and East Renfrewshire for the whole of this month.
The officers from G Division were focusing on organised criminal gangs.
Detective Inspector Alan McAlpine, who is based at Helen Street Police Office, said: "Through intelligence provided by officers and the community we were able to search a number of properties under a warrant.
"We were working under the banner of Operation Myriad."
Police also searched a home in Meiklerig Crescent in Pollok where officers recovered more than a kilogram of herbal cannabis.
Inquiries are continuing into that find.
More drugs were found at a house in Carmichael Street.
A 42-year-old male and a 37-year-old female were detained in connection with an ounce of heroin that was recovered there.
Officers also searched a home in Crossloan Road.
A 44-year-old woman was arrested for obstruction and in connection with the supply of heroin.
She will be the subject of a report to the procurator fiscal.