They say streets in the designated conservation area of Dennistoun are ridden with potholes, which is made worse by the volume of traffic.
Residents say the streets are busy because it is a main route for the Royal Infirmary and City Park, a local business park. Local people also say the streets are often used as an overspill car park.
Cliff Shea, who is retired, has lived in Broompark Drive for 39 years and does not remember the roads being resurfaced during that time.
The 67-year-old said: "The problem is just the general breaking up of the surface – and the amount of traffic does not help.
"The parking situation is so bad here that the cars always double-park along the streets, while cars going along the streets go through the rut in the middle of the road.
"That's where all the potholes come from."
Dennistoun was designated a Conservation Area by Glasgow District Council in July 1975.
It is defined as "an area of special architectural or historic interest, the character or appearance of which it is desirable to preserve or enhance".
This includes the buildings, the spaces between them and any communal gardens in the area.
Glasgow now has 23 conservation areas, varying from the city centre and Victorian residential suburbs, to a rural village and former country estate.
Dennistoun residents say the streets of Westercraigs, Oakley Terrace and Craigpark are also particularly bad.
Margaret Donarski, 75, is also retired and lives in Craigpark.
She said: "The roads are dreadful, a mess.
"The workers repair it time and time again, but it does not seem to do any good.
"It is hard to get across the road because of the number of cars that are double-parked, so it makes it hard to avoid the potholes."
A Glasgow City Council spokesman said: "Temporary patching has previously been applied and further permanent patching is scheduled within the next three months."
The Dennistoun pothole problems are the latest highlighted by the Evening Times Pothole Watch campaign.
Now in its third year, the campaign was launched to monitor and expose the poor conditions of Glasgow's roads.
Since then, the paper has helped residents combat problem areas by bringing the roads to the attention of Glasgow City Council.
Recently, we have highlighted problem areas in Hope Street, Renfrew Street in the city centre, and Wester Common Drive in Possilpark.