The Clyde Arc, at the bottom of Finnieston Street – nicknamed the Squinty Bridge because of its unusual structure – has a huge pothole in the surface of its north-bound lane hitting drivers heading from Govan to the city centre.
The affected road part starts as a bus lane ends and at a point where other traffic can merge into its two lanes.
An angry motorist, who was shocked when his tyres hit the crumbling road, said: "The hole must be around about 30ft long and it feels like you're driving through a rutted field.
"It looks like it could be from where the anti-skid surfacing has been worn away.
"I'm not sure what it means for safety, having a hole like that on a bridge."
The Evening Times' Pothole Watch campaign was launched to monitor and expose the poor conditions of Glasgow's roads.
Since then, the paper has been flooded with complaints from thousands of angry readers who have had problems with city roads.
The bridge cost £20.3million and has become a city landmark since it opened to traffic in September 2006.
Spanning 150 yards over the River Clyde, it was built as part as part of an ongoing regeneration project of the area.
It was the first new road bridge to be built over the Clyde since 1969 and has one lane dedicated to public transport and two for private and commercial traffic.
It features a central arch which crosses the river at an angle between the roundabout at Broomielaw and Finnieston Street and the south bank of the river. In October, drivers faced six weeks of traffic chaos as repair work was carried out on bus lanes.
The lane closures forced buses, taxis, and all other vehicles into one lane on the route, which becomes heavily congested at peak times.
In 2008, the bridge hit the headlines when one of its support cables snapped and crashed on the roadway.
A Glasgow City Council spokesman said: "Some surface damage has occurred on the bridge due to recent freezing temperatures.
"Temporary repairs have been scheduled with permanent repairs to be completed once temperatures rise.
"The council is spending an additional £8m on the city's roads during the current financial year."