And one of the first to congratulate him was tennis legend Andre Agassi.
The American great and former Grand Slam winner said @AndreAgassi Well deserved...Congratulations to the #USOPEN Champion Andy Murray!!!
For writer and comedian Stephen Fry the excitement was almost too much to take during the game.
After Fry tweeted @stephenfry Glory glory glory glory glory GLORY be!!! Andy Murray, you beauty! #USOpen
Piers Morgan tweeted "McBOOOOM!!!!! We are witnessing one of the greatest British sporting triumphs of my lifetime. #Murray"
Olympican DaiGreene tweeted "Waking up to find @andy_murray won the #usopen. Fantastic result, great to see him getting the win he deserves."
Hollywood legend Russell Crowe tweeted his congratulations saying "I bet there's a good drink to be had in Dunblane this night. Have a few for me."
Scots actor Alan Cumming tweeted during the match saying "oh little andy murray looks so stressed out. poor wee thing."