George Square will also be designated smoke-free when it stages its events in the run-up to Christmas.
More than 50,000 people are expected to attend tonight's fireworks spectacular, which will have a Commonwealth Games theme.
It will be the first outdoor event where smokers will be asked not to light up to protect the health of the people round about them.
The message will be reinforced on November 14 at the popular Christmas Lights Switch-on in George Square.
By the time Glasgow On Ice opens on November 23, the licensed area within George Square will be smoke-free, with stewards asking anyone who lights up to stub it out.
The move is being led by Emma Gillan, the city council's newly appointed health inequalities spokeswoman.
It is aimed at providing a smoke-free environment at all city events.
Ms Gillan said: "We all understand the dangers of smoking and it is right we do everything we can to make sure it is stubbed out at all our major events.
"Events such as the Christmas Lights Switch-On attract families with small children and we want to send the message young people should not be exposed to such a harmful habit in our civic spaces.
"I have no doubt the vast majority of people will be happy to see us move to smoke-free events."
Glasgow City Council and Glasgow Life, which runs the city's leisure activities, plan to review the smoke-free initiative with a view to extending it to cover all outdoor events planned for next year.
The move has been backed by Sheila Duffy, chief executive of health charity ASH Scotland. She said: "I warmly welcome the announcement that Glasgow's fireworks display and future outdoor events in the city will be smoke-free.
"This initiative shows further commitment to tackling the dangers of tobacco and sets an encouraging example for other local authorities in Scotland."
l Glasgow Green Fireworks - pre-show entertainment starts at 6.30pm, display starts at 7.30pm.