A new dedicated team of city detectives has launched a major assault on underworld figures since the new national police force came in to being.
The squad - the only one of its kind in Scotland - is understood to have targeted gang-linked criminals for offences ranging from serious violence and drug dealing to driving without a licence or insurance.
It has also frozen £7 million in suspected criminal assets and prevented companies acting as Mob fronts from getting another £7m in business.
Detective Superintendent John McDonald stressed his unit would use the full breadth of disruption tactics developed in recent years to target the more than 50 serious and organised crime gangs thought to operate in the city.
Mr McDonald said: "The crimes committed by these groups can range from dealing in counterfeit goods - threats and extortion - to drug dealing and firearms offences.
"We are committed to tracking these individuals down and arresting them.
"If you are engaged in organised crime, we will be carefully looking at you and how you operate.
"We will be scrutinising your finances and your assets to establish if you came by them through criminal enterprise.
"This will include: your home - your family's homes - cars, bank accounts and properties abroad."
Police Scotland have increasingly used smart tactics to tackle organised crime, including proceeds of crime legislation.
Mr McDonald and his colleagues - including forensic accountants - now go after money as much as drugs and aim to cripple gangsters financially.
In just five days in May they seized £350,000 in cash, hidden in plastic shopping bags and shoeboxes, from two homes.
This kind of cash seizure is rarely challenged by gangsters.
Mr McDonald added: "I want to reassure the people in Glasgow that we are doing everything we can to make sure that criminals do not benefit from organised crime.
"We all see the person who lives way beyond their means -- the person in your street who has never worked a day in his life yet still manages to build an expensive extension, drive an expensive car or take holidays abroad.
"Tell me who these individuals are and we can tackle these people."
The old Strathclyde Police and Scottish Crime and Drug Enforcement Agency pioneered many of these tactics.
The new Police Scotland now has a large Greater Glasgow division -the city plus East Renfrewshire and East Dunbartonshire.
This is Scotland's biggest police division and the only one to have a dedicated unit tackling organised crime.
The city and its suburbs, after all, remains effectively Scotland's underworld capital.
But Glasgow gangsters are finding life much harder than they have in the past. Police are examining their assets and investigating their front businesses.
Detective Chief Inspector Gary Thomson said: "We are continually looking at serious and organised crime groups and their business interests and will employ every means to disrupt them.
"We have had groups involved in the security industry, the pub trade and taxi firms shut down.
"Since April 2007 we have taken almost £7m in earnings from the pockets of these groups.
"The message we are sending out is, if you are a part of serious and organised crime group, we will look at your businesses.
"We have a team of financial investigators looking behind these businesses to see who is really running them. If we find that gangs are behind them, we will work to close them down.
"We have to remember the law-abiding people out there who want to set up business but can't get that foothold because the criminals have got a tight grip on the market. Well, not any more."
Police readily admit that crime statistics rarely show whether they have been effective in fighting organised crime.
However, insiders are happy to acknowledge that some of the recent decline in violent crime in Glasgow is down to action against gangsters.
The Evening Times Crime on Your Street investigation, meanwhile, has found that the number of drug possession raps is rising.
There were nearly 8000 in 2012-13, the highest figure since we began our series in 2006-2007.
This would appear to reflect the massive rise in stop-and-searches by police.
The number of drug dealing crimes recorded, however, has fallen, almost by half to 740 in 2012-13 in the city of Glasgow.
The latest round of arrests of underworld figures may boost that figure in 2013-14, however, Mr McDonald said his unit had arrested 380 drug dealers since April of this year.
That figure overlaps with the 350 gang-linked arrests over the same period.