A previous bid to create a so-called Business Improvement District (BID) in the area collapsed when the entire project's management committee resigned in a row with East Renfrewshire Council over town-centre parking charges.
A review of council parking policy has since been launched.
Now, just three months after the first BID plan failed, businesses in the town have backed a new management committee.
Clarkston's traders face what they see as a continual battle against out-of-town shopping malls, and are desperate to keep local customers.
Now a number of business figures led by Gordon Paterson of Living for Style and Lisa McLaughlin of Ollaberry have decided to take action and muster wide support across Clarkston.
That has led to a new management committee being set up
Mr Paterson said: "I was annoyed that the last committee resigned over one issue, parking, especially when it had been so successful on a number of other fronts.
"While I realise that many businesses are against the BID and some of us are apathetic, there is also a considerable amount of support and I feel that with joined-up help from businesses, council, government and local groups we can use any funding obtained to avoid Clarkston going into further decline and return it to a reasonable shopping area that it deserves.
"We will begin by pushing for a Christmas event and then we can look to improve parking, refresh our marketing strategy, and carry out a review of the existing business plan.
"Together we can make a difference."
Roy Provan, Director of East Renfrewshire BIDs, added: "It is pleasing to see a significant number of Clarkston businesses have taken the initiative to start driving the BID forward again."