Maintenance, which bosses said will make the bridge safer, is to begin on Monday, August 11.
The works are to take place during off-peak periods only and are being planned for Monday to Friday between 9.30am and 3.30pm.
Russell Rennie, Scotland TranServ's Contract Director, said: "Every effort has been taken to reduce any further disruption for local commuters who have been incredibly patient while these essential safety works were carried out.
"It was important to Scotland TranServ and Transport Scotland that any completion works be carried out off-peak.
"This important work will make the Erskine Bridge one of the safest such crossings in the country and create a good first impression for summer visitors using the bridge as a gateway to Loch Lomond, Argyll and the Highlands."
Works will spark single lane offside closures at the north end of the bridge.
Some closures to the A82/A898 northbound off slip to Clydebank will also be necessary, with traffic being diverted via the A82 Dunglass roundabout and return.
Work will include replacement of the central reserve crossover barrier and the the adjoining low-level central reserve barriers at the north end of the bridge, and 50 mph terminal signs at the north and south ends of the bridge will be installed.
Bosses added that they are planning to cause minimal distruption to travellers.