Officers will be targeting motorists during a two-week blitz on those who get behind the wheel while under the influence of alcohol or drugs.
Superintendent Iain Murray warned drivers they could face a 20 year criminal record even if they are "just over" the limit.
Police believe barbecues, weddings, and summer parties will increase the temptation to have a drink before getting behind the wheel.
Superintendent Murray, Head of Road Policing at Police Scotland, said: "Our message this summer is clear.
"Those who get behind the wheel while under the influence of drink or drugs will be caught.
"In Scotland there has never been a greater priority and focus on casualty reduction and making our roads safer.
"Drink drivers, no matter how little they are over the limit, will face serious consequences.
"These include a lengthy criminal record, an automatic driving ban, having their car seized, a fine of up to £5,000 and the possibility of a prison sentence.
"Police Scotland will hammer home the message this summer through tough enforcement that drinking and driving is unacceptable and ruins hundreds of lives each year.
"Don't ever drink and drive."
It comes as the Scottish Government revealed plans to slash the drink-drive limit.
Justice Secretary Kenny MacAskill said: "Having just one alcoholic drink, then driving, makes you three times more likely to be involved in a fatal car crash.
"I am determined that we do everything we can to make our roads safer and save lives.
"That's why we will soon be lowering the drink drive limit to 50 mg of alcohol in every 100 ml of blood."
Police Scotland launched the clampdown in conjunction with the Crown Office, Scottish Government and Road Safety Scotland.
Officers are also urging motorists to avoid driving if they are suffering from a hangover.
Scotland's top law officer, The Lord Advocate, Frank Mulholland QC, said: "If you are drinking or taking drugs do not get behind the wheel of a car.
By doing so you may risk your licence, your liberty, your car and the life of yourself and others.
"My message is very clear; you will be caught and when you are, you will be prosecuted to the full extent of the law".
If you suspect someone of drink driving, call Police Scotland on 101. In an emergency, you can also dial 999.