The accident happened at around 6.30am this morning in South Lanarkshire, near the Lesmahagow junction.
Police closed the motorway between junctions 12 and 10, northbound.
A lane is also closed on the southbound carriageway, at junction 11, as work to recover the lorry is ongoing.
Police say no one was injured.
Drivers heading south on the M74 have reported queues of up to 45 minutes.
Traffic Scotland has advised motorists to take care while driving in this area.